Endocrine Abstracts

Background: In severe obesity, hypogonadism in men and androgen excess in women are frequently observed. Sex hormones play an important role in body composition, glucose and lipid metabolism. Bariatric surgery is the most effective treatment strategy to combat morbid obesity. However, if preoperative gonadal dysfunction impacts weight loss and metabolic improvements after surgery is not known.Methods: 49 men and 104 women were included in a retrospective...

Background: Craniopharyngiomas (CP) are benign brain tumours presenting in childhood treated by tumour resection together with radiotherapy. In about half of the cured patients hypothalamic damage leading to eating disorders and obesity as well as to hypopituitarism, necessitating consequent hormone substitution therapy, is observed. Bariatric surgery is an efficient treatment strategy for morbid obesity. However, so far it is unknown, whether oral hormone substitution is hamp...

Osteopontin (OPN) is a multifunctional glycoprotein implicated, among others, in bone metabolism, cardiovascular disease, diabetes and obesity. It promotes inflammation and insulin resistance. Osteopontin is elevated in the plasma and adipose tissue of obese subjects and decreases upon diet induced weight loss. Here we investigated the effect of bariatric surgery on plasma OPN concentrations in morbidly obese patients. 40 obese patients aged 43.1±1.8 years were recruited ...

Recent case reports describe hyperinsulinemic hypoglycemia after gastric bypass. The aim of this study was the assessment of insulin resistance and insulin secretion in non-diabetic morbidly obese patients before and six months after bariatric surgery.In 8 non-diabetic morbidly obese patients (OB:6f/2 m, age:42±3a, BMI:47.29±2.2 kg/m2) and 6 controls (CON:4f/2 m, age:43±0a, BMI:23.8±0.5 kg/m2) we performed a freq...